Onalespib

INN name:	Onalespib
Lab codes:	AT-13387
Chemical name:	[2,4-dihydroxy-5-(propan-2-yl)phenyl]{5-[(4-methylpiperazin-1-yl)methyl]-1,3dihydro-2H-isoindol-2-yl}methanone
Molecular formula:	C24H31N3O3
Chemical Structure:
CAS Registry Number:	912999-49-6
Originator:	Astex Therapeutics
Developer:	Astex Pharmaceuticals; National Cancer Institute
Class:	Antineoplastics
Mechanism of Action:	Heat Shock Protein-90 (HSP90) Inhibitor
WHO ATC code:	L01
EPhMRA code:	L1
Clinical Trials Conditions Phases Interventions Recruitment Gastrointestinal Stromal Tumor (GIST) Phase 2 Alone or in combination Completed Prostate Cancer Phase 1|Phase 2 Alone or in combination Completed Non-small Cell Lung Cancer(NSCLC) Phase 1|Phase 2 Alone or in combination Active, not recruiting Recurrent Non-Small Cell Lung Carcinoma|Stage IV Non-Small Cell Lung Cancer Phase 1|Phase 2 combination Not yet recruiting Adult Solid Neoplasm Phase 1 combination Not yet recruiting Advanced Triple Negative Breast Cancer Phase 1 combination Not yet recruiting Advanced Squamous Cell Carcinoma of the Head and Neck Phase 1 combination Not yet recruiting Recurrent Melanoma or Solid Tumors Phase 1 combination Suspended Solid Tumors|Breast Cancer Phase 1 Alone Completed Metastatic Solid Tumors Phase 1 Alone Completed
Recent activities on the drug: